Premalignant Lesions of Urinary Bladder Mucosae

Premalignant lesions of mucosae urinary bladder are flat, noninvasive lesions of urothelium such as atypical hyperplasia/dysplasia and nonpapillary carcinoma in situ (CIS). The aim of this study was to identify association between premalignant lesions and subsequent invasive carcinoma. The study includes 60 patients with diagnosed noninvasive superficial and invasive bladder tumors. Our examination suggested that atypical hyperplasia/dysplasia and in situ carcinoma were more frequent in the higher grade and pathologic staging. In our material we had three patients with this concomitant lesions. Essential events in evaluation bladder urothelial carcinoma is grading, pathological staging and identification of premalignant lesions of mucosae urinary bladder. The authors suggest that the identification of patients with urothelial CIS and atypical hyperplasia/dysplasia is a particularly important event, representing the locus minoris resistentiae for the development of invasive bladder cancer.